To get a full understanding of how these work, as I commented on one of your other posts, you would need to read ODS I & II, which are pretty much the definitive guides to the two concepts. Also, on box pleating, there are a few tutorials hidden on this forum, if you search for them hard enough. With regards to box pleating, find the basic dimensions of the Model you want to fold, then base those dimensions on your box pleating density. I.e, for a human, you're looking for a density of around 24, because of the thickness of the limbs. Then, crease a grid on the piece of paper you want to use. This is the basic building concept for what you are about to do. Let each limb on your model be a point on the paper. Now, draw where you want those limbs to be located on the paper. It's generally up to your common sense for this. for a human, you would place hands and feet in the corners, and the head on the halfway point between the two hand corners. For an animal with a tail, you would place the tail point between the two feet. ODS gives a variety of techniques for how to separate these points, so that they actually begin to form what you want to create. With regards to creating a model with a "natural appearance", and removing the boxlike form,
This might help you.
Also, choosing where you want your points also applies to circle packing.
I don't design models, so I can't give you much more help.